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SR-121463A 185913-79-5
价格:8800元/公斤 含量:99% 包装:25公斤
CAS;185913-79-5
分子式：C17H22ClNO3
分子量：323.8228
化学名称 N-tert-Butyl-4-[5'-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2'-oxospiro
[cyclohexane-1,3'-indolin]-1'-ylsulfonyl]-3-methoxybenzamide fumarate
The reduction of diethyl 3-(methoxymethoxy)glutarate (I) with LiAlH4 in THF gives
3-(methoxymethoxy)pentane-1,5-diol (II), which is treated with Ts-OH and TEA in
THF to yield the disulfonate (III). The condensation of (III) with 5-
ethoxyindolin-2-one (IV) by means of tBu-OK in THF affords the spiro compound (V),
which is deprotected with HCl in methanol to afford the spiranic alcohol (VI). The
oxidation of (VI) with pyridinium chlorochromate (PCC) over Al2O3 provides the
spiranic cyclohexanone (VII), which is treated with 2-chloroethanol (VIII) and
Ms-OH in toluene to give the ketal (IX). The reaction of (IX) with zinc
borohydride and trimethylsilyl chloride in ethyl ether/dichloromethane yields the
2-chloroethoxy derivative (X), which is condensed with 4-(N-tert-butylcarbamoyl)-
2-methoxybenzenesulfonyl chloride (XI) by means of tBu-OK in THF to afford the
adduct (XII). Finally, the target compound is obtained by condensation of (XII)
with morpholine (XIII) by means of NaI in DMF, followed by treatment with fumaric
acid.
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693-13-0 21409-26-7 +V;yyjszz957 Q3218928779
